Athanasios Typas

Jun 5, 2024 | nature.com | Iskander Khusainov |Camille V. Goemans |Christian Zimmerli |Sonja Welsch |Julian D. Langer |Athanasios Typas

AbstractRibosomes translate the genetic code into proteins. Recent technical advances have facilitated in situ structural analyses of ribosome functional states inside eukaryotic cells and the minimal bacterium Mycoplasma. However, such analyses of Gram-negative bacteria are lacking, despite their ribosomes being major antimicrobial drug targets. Here we compare two E. coli strains, a lab E. coli K-12 and human gut isolate E.

Jun 26, 2023 | nature.com | Josy ter Beek |Laura Alvarez |André Mateus |Remy Colin |Athanasios Typas |Mikhail M. Savitski | +3 more

AbstractTo explore favourable niches while avoiding threats, many bacteria use a chemotaxis navigation system. Despite decades of studies on chemotaxis, most signals and sensory proteins are still unknown. Many bacterial species release d-amino acids to the environment; however, their function remains largely unrecognized. Here we reveal that d-arginine and d-lysine are chemotactic repellent signals for the cholera pathogen Vibrio cholerae.