Stanley Perlman

Oct 14, 2024 | nature.com | Stanley Perlman |Alan Sariol

A hallmark of post-viral lung disease, including post-acute sequelae of COVID-19, is dysplastic lung repair. CD8+ T cells contribute to aberrant repair through induction by IFNγ and TNF of IL-1β in macrophages, halting differentiation of alveolar type 2 cells.

Jul 24, 2024 | nature.com | David Meyerholz |Fan Bu |Bin Liu |Fang Li |Stanley Perlman

AbstractAlthough Omicron RBD of SARS-CoV-2 accumulates many mutations, the backbone region (truncated RBD) of spike protein is highly conserved.

May 13, 2024 | nature.com | Ruipeng Lei |Enya Qing |Meng Yuan |Ian Wilson |Tom Gallagher |Stanley Perlman | +1 more

AbstractThe fusion peptide of SARS-CoV-2 spike protein is functionally important for membrane fusion during virus entry and is part of a broadly neutralizing epitope. However, sequence determinants at the fusion peptide and its adjacent regions for pathogenicity and antigenicity remain elusive.

Feb 15, 2023 | nature.com | Stanley Perlman |Malik Peiris

Decades of coronavirus research and intense studies of SARS-CoV-2 since the beginning of the COVID-19 pandemic have led to an unprecedented level of knowledge of coronavirus biology and pathogenesis, yet many outstanding questions remain. Here, we discuss knowledge gaps and research priorities in the field.