Ruipeng Lei

May 13, 2024 | nature.com | Ruipeng Lei |Enya Qing |Meng Yuan |Ian Wilson |Tom Gallagher |Stanley Perlman | +1 more

AbstractThe fusion peptide of SARS-CoV-2 spike protein is functionally important for membrane fusion during virus entry and is part of a broadly neutralizing epitope. However, sequence determinants at the fusion peptide and its adjacent regions for pathogenicity and antigenicity remain elusive.

Sep 14, 2023 | biorxiv.org | Yiquan Wang |Huibin Lv |Ruipeng Lei |Yuen-Hei Yeung

AbstractDespite decades of antibody research, it remains challenging to predict the specificity of an antibody solely based on its sequence. Two major obstacles are the lack of appropriate models and inaccessibility of datasets for model training. In this study, we curated a dataset of >5,000 influenza hemagglutinin (HA) antibodies by mining research publications and patents, which revealed many distinct sequence features between antibodies to HA head and stem domains.