Alan Sariol

2 months ago | cell.com | Saravanan Raju |Sathvik Palakurty |Alan Sariol |Ngan Wagoner |Lucas Adams |Sean Hui | +3 more

Keywords alphavirus receptor structure pathogenesis therapy cryoelectron microscopy Introduction Alphaviruses are arthropod-transmitted viruses that infect many vertebrate hosts.1 The encephalitic alphaviruses, including Eastern equine encephalitic virus (EEEV), Venezuelan equine encephalitic virus (VEEV), and Western equine encephalitic virus (WEEV), are neurotropic in both horses and humans and cause lethality or long-term neurological sequelae.2 Whereas some bird species serve as enzootic...

Oct 14, 2024 | nature.com | Stanley Perlman |Alan Sariol

A hallmark of post-viral lung disease, including post-acute sequelae of COVID-19, is dysplastic lung repair. CD8+ T cells contribute to aberrant repair through induction by IFNγ and TNF of IL-1β in macrophages, halting differentiation of alveolar type 2 cells.

Oct 5, 2024 | cell.com | Alan Sariol |Lucas Adams |Sean Whelan |Camille Carmona

KeywordsReceptoralphaviruspathogenesisdecoytherapytropismResearch topic(s)CP: MicrobiologyCP: ImmunologyIntroductionAlphaviruses are arthropod-transmitted, enveloped, positive-strand RNA viruses that cause musculoskeletal disease or encephalitis in humans.