Stathis Megas

Nov 20, 2024 | nature.com | J. Patrick Pett |Kenny Roberts |Raphael Blain |Krzysztof Polanski |Peng He |Chuan Xu | +18 more

AbstractHuman embryonic bone and joint formation is determined by coordinated differentiation of progenitors in the nascent skeleton. The cell states, epigenetic processes and key regulatory factors that underlie lineage commitment of these cells remain elusive.

Aug 26, 2024 | journals.plos.org | Stathis Megas |Nadav Yayon |Kerstin B Meyer

Recent progress in the field of single-cell biology has led to an explosion of data providing molecular descriptions of individual cells and cell types, which are increasingly mapped into their tissue context. Dissociated single cells are now routinely profiled by combining multiple molecular features—mainly, the transcriptome, metabolome, and proteome. However, what is as yet missing is a better link to the morphological description of cells and tissues.