Kenny Roberts

Nov 20, 2024 | nature.com | J. Patrick Pett |Kenny Roberts |Raphael Blain |Krzysztof Polanski |Peng He |Chuan Xu | +18 more

AbstractHuman embryonic bone and joint formation is determined by coordinated differentiation of progenitors in the nascent skeleton. The cell states, epigenetic processes and key regulatory factors that underlie lineage commitment of these cells remain elusive.

Aug 19, 2024 | nature.com | David Horsfall |Daniela Basurto-Lozada |Kenny Roberts |Martin Prete |Peng He |Josh Moore | +5 more

Multimodal tissue atlasing datasets pose two key challenges for online dissemination and equitable access. First, single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics data objects are often saved in non-unified sequencing and imaging file formats that perform poorly with web technologies. Second, existing software platforms do not readily support simultaneous browsing of multiple integrated data modalities.

Dec 21, 2023 | biorxiv.org | Steven Woods |Kenny Roberts |Dinithi Sumanaweera |Petra Balogh

AbstractThe consistent production of in vitro chondrocytes that faithfully recapitulate in vivo development would be of great benefit for musculoskeletal disease modelling and regenerative medicine. Current efforts are often limited by off-target differentiation, resulting in a heterogeneous product. Furthermore, the lack of comparison to human embryonic tissue, precludes detailed evaluation of in vitro cells.

May 22, 2023 | biorxiv.org | Daniela Basurto-Lozada |Kenny Roberts |Martin Prete |David Horsfall

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