Stefan Gahbauer

Dec 6, 2023 | nature.com | Stefan Gahbauer |Joao M. Braz |Hye Jin Kang |Christian B. Billesbølle |Yongfeng Liu |Tao Che | +7 more

AbstractThe lipid prostaglandin E2 (PGE2) mediates inflammatory pain by activating G protein-coupled receptors, including the prostaglandin E2 receptor 4 (EP4R). Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce nociception by inhibiting prostaglandin synthesis, however, the disruption of upstream prostanoid biosynthesis can lead to pleiotropic effects including gastrointestinal bleeding and cardiac complications.