Stephanie Tam

Nov 22, 2024 | biorxiv.org | Swati Pant |Stephanie Tam |Stephen Long

AbstractBestrophin 1 (BEST1) is chloride channel expressed in the eye, central nervous system (CNS), and other tissues in the body. A link between BEST1 and the principal inhibitory neurotransmitter gamma-aminobutyric acid (GABA) has been proposed. The most appreciated receptors for extracellular GABA are the GABAB G-protein coupled receptors and the pentameric GABAA chloride channels, both of which have fundamental roles in the CNS. Here, we demonstrate that BEST1 is directly activated by GABA.

Apr 22, 2024 | onlinelibrary.wiley.com | Stephanie Tam |Darcy Wear |Christopher D. Morrone |Wai Haung Yu

ɑ-syn ɑ-synuclein Aβ amyloid β AβO amyloid β oligomers AD Alzheimer's disease ADSC adipose-derived stem cell ALS amyotrophic lateral sclerosis A-LS autophagic-lysosomal system ASO antisense oligonucleotides ATP adenosine triphosphate CJD Creutzfeldt-Jakob disease CNS central nervous system CSF cerebrospinal fluid DLB dementia with Lewy bodies ER endoplasmic reticulum EV extracellular vesicle EVM extracellular vesicle mimetic FTD frontotemporal degeneration FUS fused in sarcoma GRN progranulin...

Aug 27, 2023 | www150.statcan.gc.ca | Stephanie Tam

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Mar 31, 2021 | believermag.com | Stephanie Tam

Nov 16, 2020 | www150.statcan.gc.ca | Stephanie Tam