Swati Pant

Nov 22, 2024 | biorxiv.org | Swati Pant |Stephanie Tam |Stephen Long

AbstractBestrophin 1 (BEST1) is chloride channel expressed in the eye, central nervous system (CNS), and other tissues in the body. A link between BEST1 and the principal inhibitory neurotransmitter gamma-aminobutyric acid (GABA) has been proposed. The most appreciated receptors for extracellular GABA are the GABAB G-protein coupled receptors and the pentameric GABAA chloride channels, both of which have fundamental roles in the CNS. Here, we demonstrate that BEST1 is directly activated by GABA.

Apr 17, 2023 | onmanorama.com | Swati Pant

Hyderabad conjures up the image of a city that has its soul in the past but lives in the present. The aromatic biryanis of Secunderabad, the time-ravaged tombs of the Qutub Shahis, the lit-up choodi-bazaar of Charminar which look like an Arabian dream, and the modernity that whizzes past you near Begumpet and Hussain Sagar tank, are all equally vibrant. Say Hyderabad and three things come to mind almost instantly — Biryani, Charminar, and Biscuits.