Stephen Gottschalk

3 weeks ago | britannica.com | Stephen Gottschalk |J. Gordon Melton

Christian Science, religious denomination founded in the United States in 1879 by Mary Baker Eddy, author of the book that contains the definitive statement of its teaching, Science and Health with Key to the Scriptures (1875). It is widely known for its highly controversial practice of spiritual healing.

Apr 24, 2024 | nature.com | Meenakshi Hegde |Shoba Navai |Khaled Sanber |Ahmed Gad |Riyue Bao |Ahmed Salem | +5 more

AbstractIn this prospective, interventional phase 1 study for individuals with advanced sarcoma, we infused autologous HER2-specific chimeric antigen receptor T cells (HER2 CAR T cells) after lymphodepletion with fludarabine (Flu) ± cyclophosphamide (Cy): 1 × 108 T cells per m2 after Flu (cohort A) or Flu/Cy (cohort B) and 1 × 108 CAR+ T cells per m2 after Flu/Cy (cohort C). The primary outcome was assessment of safety of one dose of HER2 CAR T cells after lymphodepletion.

Nov 8, 2023 | nature.com | Caleb A Lareau |Yajie Yin |Katie Maurer |Katalin Sandor |Bence Daniel |Jose Sanz Peña | +20 more

AbstractCell therapies have yielded durable clinical benefits for patients with cancer, but the risks associated with the development of therapies from manipulated human cells are understudied. For example, we lack a comprehensive understanding of the mechanisms of toxicities observed in patients receiving T cell therapies, including recent reports of encephalitis caused by reactivation of human herpesvirus 6 (HHV-6)1.