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Oct 4, 2024 | 
nature.com | Junhao Wen |Ilya M. Nasrallah |Guray Erus |Jingxuan Bao |Andrew J. Saykin |Timothy J. Hohman | +11 more
AbstractAlzheimer’s disease (AD) is associated with heterogeneous atrophy patterns. We employed a semi-supervised representation learning technique known as Surreal-GAN, through which we identified two latent dimensional representations of brain atrophy in symptomatic mild cognitive impairment (MCI) and AD patients: the “diffuse-AD” (R1) dimension shows widespread brain atrophy, and the “MTL-AD” (R2) dimension displays focal medial temporal lobe (MTL) atrophy.
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Aug 15, 2024 | 
nature.com | Zhijian Yang |Junhao Wen |Guray Erus |Elizabeth Mamourian |Katharina Wittfeld |Duygu Tosun | +17 more
AbstractBrain aging process is influenced by various lifestyle, environmental and genetic factors, as well as by age-related and often coexisting pathologies. Magnetic resonance imaging and artificial intelligence methods have been instrumental in understanding neuroanatomical changes that occur during aging.
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Jul 18, 2024 | 
nature.com | Juan Fortea |Daniel Alcolea |Olivia Belbin |Oriol Dols-Icardo |Laura Videla |Marc Suárez-Calvet | +4 more
replying to C. Pappalettera et al. Nat. Med. https://doi.org/10.1038/s41591-024-03158-5 (2024)Pappalettera et al.1 raise important points concerning our recent publication on APOE4 homozygotes2, specifically about the definition of Alzheimer’s disease (AD), resilience factors, and the ethical implications of diagnosing asymptomatic individuals.
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Jun 17, 2024 | 
nature.com | Juan Fortea |Jordi Pegueroles |Daniel Alcolea |Olivia Belbin |Oriol Dols-Icardo |Laura Videla | +5 more
Correction to: Nature Medicine https://doi.org/10.1038/s41591-024-02931-w, published online 6 May 2024In the version of the article initially published, the title of Fig. 4 read “APOE3 homozygotes” and has now been amended to “APOE4 homozygotes” in the HTML and PDF versions of the article. About this articleFortea, J., Pegueroles, J., Alcolea, D. et al. Publisher Correction: APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease. Nat Med (2024).
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May 11, 2024 | 
truthout.org | Sterling Johnson
A new report reveals the city’s plans to clear homeless encampments and jail vulnerable residents.
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May 8, 2024 | 
prismreports.org | Sterling Johnson
The city of Philadelphia has released a 100-day Public Safety Plan with a section focused on cleaning up the “open-air drug market” in the city’s Kensington neighborhood. The release follows recent reports that the city’s jails are violent and understaffed, leading criminal legal advocates to call for a different solution to protect vulnerable communities living on the streets.
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May 6, 2024 | 
nature.com | Juan Fortea |Jordi Pegueroles |Daniel Alcolea |Olivia Belbin |Oriol Dols-Icardo |Laura Videla | +5 more
AbstractThis study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer’s disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD. Data from the National Alzheimer’s Coordinating Center and five large cohorts with AD biomarkers were analyzed. The analysis included 3,297 individuals for the pathological study and 10,039 for the clinical study.
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Jan 7, 2024 | 
nature.com | Zhijian Yang |Junhao Wen |Ahmed Abdulkadir |Guray Erus |Luigi Ferrucci |Sterling Johnson | +6 more
AbstractDisease heterogeneity has been a critical challenge for precision diagnosis and treatment, especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple distinct brain phenotypes across individuals, potentially reflecting disease subtypes that can be captured using MRI and machine learning methods. However, biological interpretability and treatment relevance are limited if the derived subtypes are not associated with genetic drivers or susceptibility factors.
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Jan 4, 2024 | 
nature.com | Sterling Johnson |Kaj Blennow |Henrik Zetterberg
AbstractBreakdown of the neurovascular unit is associated with blood-brain barrier (BBB) leakiness contributing to cognitive decline and disease pathology in the early stages of Alzheimer’s disease (AD). Vascular stability depends on angiopoietin-1 (ANGPT-1) signalling, antagonised by angiopoietin-2 (ANGPT-2) expressed upon endothelial injury.
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Apr 25, 2023 | 
dialnet.unirioja.es | Sterling Johnson
Philadelphia Housing Action: Covid-19 pandemic and negotiating our survivalAutores: Sterling JohnsonLocalización: Partecipazione e conflitto, ISSN-e 2035-6609, Vol. 16, Nº. 1, 2023 (Ejemplar dedicado a: Special Issue on: "Housing Crisis and Social Mobilization in times of COVID19"), págs. 115-118Idioma: inglésEnlacesTexto completoResumenPhiladelphia Housing Action is a group of experienced housing organizers formed at the beginning of the Covid-19 pandemic.
