Steven G. Rozen

Jan 9, 2025 | biorxiv.org | Nanhai Jiang |Yang Wu |Steven G. Rozen

AbstractMutational signatures are characteristic patterns of mutations caused by endogenous mutational processes or by exogenous mutational exposures. There has been little benchmarking of approaches for determining which signatures are present in a sample and estimating the number of mutations due to each signature. This problem is referred to as "signature attribution".

Nov 8, 2024 | biorxiv.org | Nanhai Jiang |Yang Wu |Steven G. Rozen

AbstractMutational signatures are characteristic patterns of mutations caused by endogenous mutational processes or by exogenous mutational exposures. There has been little benchmarking of approaches for determining which signatures are present in a sample and estimating the number of mutations due to each signature. This problem is referred to as "signature attribution".

May 22, 2024 | biorxiv.org | Nanhai Jiang |Yang Wu |Steven G. Rozen

AbstractMutational signatures are characteristic patterns of mutations caused by endogenous mutational processes or by exogenous mutational exposures. Much research has focused on the problem of inferring mutational signatures as latent variables in somatic mutation data from multiple tumors. However, the problem of determining which signatures are present in a given sample and how many mutations each signature is responsible for has received negligible attention.

Feb 14, 2024 | nature.com | Lei Chen |Chong Zhang |Ruidong Xue |Mo Liu |Yin Wang |Nanhai Jiang | +9 more

AbstractOver half of hepatocellular carcinoma (HCC) cases diagnosed worldwide are in China1,2,3. However, whole-genome analysis of hepatitis B virus (HBV)-associated HCC in Chinese individuals is limited4,5,6,7,8, with current analyses of HCC mainly from non-HBV-enriched populations9,10. Here we initiated the Chinese Liver Cancer Atlas (CLCA) project and performed deep whole-genome sequencing (average depth, 120×) of 494 HCC tumours.