Sudarshan Bhattacharjee

Jan 23, 2025 | insight.jci.org | JCI Insight |Sudarshan Bhattacharjee |Jianing Gao |Yao Lu

AbstractDiabetes mellitus can cause impaired and delayed wound healing, leading to lower extremity amputations; however, the mechanisms underlying the regulation of vascular endothelial growth factor–dependent (VEGF-dependent) angiogenesis remain unclear. In our study, the molecular underpinnings of endothelial dysfunction in diabetes are investigated, focusing on the roles of disabled-2 (Dab2) and Forkhead box M1 (FOXM1) in VEGF receptor 2 (VEGFR2) signaling and endothelial cell function.

Aug 27, 2024 | biorxiv.org | Sudarshan Bhattacharjee |Jianing Gao |Yao Lu |Shahram Eisa-Beygi

AbstractDiabetes mellitus can cause impaired and delayed wound healing, leading to lower extremity amputations; however, the mechanisms underlying the regulation of vascular endothelial growth factor (VEGF)-dependent angiogenesis remain uncertain and could reveal new therapeutic targets.

Feb 9, 2024 | biorxiv.org | Sudarshan Bhattacharjee |Hao Wu |Beibei Wang |Kui Cui

AbstractThis study investigates the molecular underpinnings of endothelial dysfunction in diabetes, focusing on the roles of Disabled-2 (Dab2) and Forkhead Box M1 (FoxM1) in VEGFR2 signaling and endothelial cell function. Our research reveals critical insights into the downregulation of Dab2 and FoxM1 in endothelial cells (ECs) under hyperglycemic conditions that leads to impaired angiogenesis and delayed wound healing.

Jul 20, 2023 | frontiersin.org | Hong Ru Chen |Jian Xu |Sudarshan Bhattacharjee

Introduction An estimated 39%–49% of the world population is overweight or obese (1, 2), and this condition significantly contributes to cardiovascular morbidity and mortality through the systemic dysregulation of inflammatory cytokines (3). Chronic obesity promotes dysfunctional adipose tissue remodeling, resulting in decreased circulation of anti-inflammatory adipokines and increased pro-inflammatory adipokines (3, 4).

Mar 3, 2023 | bfsi.economictimes.indiatimes.com | Sudarshan Bhattacharjee

The latest data on sectoral deployment of credit by scheduled commercial banks (SCBs) showed that the credit growth continued its robust uptick with non-food credit registered a growth of 16.7% year-on-year in January 2023 vis-à-vis 8.3% same month of last year. Agriculture sector remained buoyant with a credit growth of 14.4% year-on-year in January 2023.