Sunil R. Lakhani

Jan 23, 2025 | nature.com | Fresia Pareja |Rohit Bhargava |Virginia F. Borges |Edi Brogi |Fatima Cardoso |Christine Desmedt | +16 more

AbstractSpecial histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. Novel methodologies, such as artificial intelligence may improve classification. Genetic predisposition plays roles in a subset of cases. Uncommon BC presentations like male, inflammatory and pregnancy-related BC pose challenges.

Nov 24, 2023 | nature.com | Brad Balderson |Jun Xu |Laura F. Grice |Pui Yeng Lam |Priyakshi Kalita-de Croft |Sunil R. Lakhani | +2 more

AbstractSpatial transcriptomics (ST) technologies generate multiple data types from biological samples, namely gene expression, physical distance between data points, and/or tissue morphology. Here we developed three computational-statistical algorithms that integrate all three data types to advance understanding of cellular processes.