Systemic Diseases

Nov 5, 2024 | academic.oup.com | Systemic Diseases

Dendritic cells (DCs) are closely related to blood pressure (BP) regulation. Mineralocorticoid receptor (MR) is an important drug target for antihypertensive treatment. However, the role of DC MR in the pathogenesis of hypertension has not been fully elucidated. This study aimed to determine the role of DC MR in BP regulation and to explore the mechanism. Renal biopsy and peripheral blood samples were collected from hypertensive patients (HTN) for immunostaining and flow cytometry.

Nov 7, 2023 | academic.oup.com | Hôpital Saint-Antoine |Université Paris Descartes |Systemic Diseases

Heart involvement is one of the leading causes of death in systemic sclerosis (SSc). The prevalence of SSc-related cardiac involvement is poorly known. Our objective was to investigate the prevalence and prognosis burden of different heart diseases in a nationwide cohort of patients with SSc. We used data from a multicentric prospective study using the French SSc national database. Focusing on SSc-related cardiac involvement, we aimed to determine its incidence and risk factors.

Sep 12, 2023 | thelancet.com | Systemic Diseases |Hôpital Cochin |Nathalie Costedoat-Chalumeau

Tapering or discontinuing SLE treatments: when and how? - The Lancet Rheumatology

Aug 9, 2023 | acrjournals.onlinelibrary.wiley.com | Yann Nguyen |Systemic Diseases |Hôpital Cochin |Benoit Blanchet

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/art.42645.

Jun 27, 2023 | jneuroinflammation.biomedcentral.com | Shanghai Jiao Tong |Systemic Diseases

The major result of the current study is that the pathological process of AD may cause impairment in the periodontium in the middle-aged mice, especially in alveolar bone in females, suggesting that periodontal bone resorption in AD mice is sex- and age-related. Homeostatic imbalance between regulatory T cells (e.g., Treg) and effector T cells (Th1, Th2, and Th17) may be the underlying mechanism. However, this immune state is independent of sex and age.