Yann Nguyen

Dec 25, 2024 | acrjournals.onlinelibrary.wiley.com | Yann Nguyen |Hôpital Bicêtre |Assistance Publique

Objective Recently, three distinct phenotypes of patients with Sjögren disease (SjD) have been described based on cluster analysis: B cell active with low symptoms (BALS), high systemic activity (HSA), and low systemic activity with high symptoms (LSAHS). We aimed to assess whether these clusters were associated with distinct biomarkers and the prognostic value of interferon (IFN) signature.

Mar 1, 2024 | thelancet.com | Yann Nguyen |Hôpital Bicêtre |Assistance Publique

SummarySjögren's disease is a heterogenous autoimmune disease with a wide range of symptoms—including dryness, fatigue, and pain—in addition to systemic manifestations and an increased risk of lymphoma. We aimed to identify distinct subgroups of the disease, using cluster analysis based on subjective symptoms and clinical and biological manifestations, and to compare the prognoses of patients in these subgroups.

Dec 17, 2023 | nature.com | Yann Nguyen

AbstractSjögren syndrome is a phenotypically varied autoimmune disorder that can occur alone in primary Sjögren syndrome or in association with other connective tissue diseases (CTDs), including rheumatoid arthritis, systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). The estimation of the prevalence and incidence of Sjögren syndrome varies depending on diagnostic criteria and study design, making it difficult to estimate geographical and temporal trends.

Aug 9, 2023 | acrjournals.onlinelibrary.wiley.com | Yann Nguyen |Systemic Diseases |Hôpital Cochin |Benoit Blanchet

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/art.42645.