Tal Ashuach

Nov 11, 2024 | arxiv.org | Ryan Conrad |Tal Ashuach

Sep 29, 2023 | biorxiv.org | Jiayi Liu |Tal Ashuach |Fumitaka Inoue |Nadav Ahituv

AbstractThe advent of the perturbation-based massively parallel reporter assays (MPRAs) technique has enabled delineating of the roles of non-coding regulatory elements in orchestrating gene expression. However, computational efforts remain scant to evaluate and establish guidelines for sequence design strategies for perturbation MPRAs. Here, we propose a framework for evaluating and comparing various perturbation strategies for MPRA experiments.