Jiayi Liu

Mar 7, 2025 | nature.com | Jiayi Liu |Chuanyu Ma |Jie Qin |Peng Zhang |Yifu Leng

There is increasing recognition of the role of oxidative balance in testosterone deficiency (TD). This study investigates the association between the oxidative balance score (OBS) and TD prevalence among adult males in the United States. Data were obtained from a cross-sectional study of 3276 adult men in the 2011–2016 National Health and Nutrition Examination Survey. OBS was assessed based on 16 nutrient and 4 lifestyle components. Multivariate logistic regression and subgroup analyses were conducted to calculate the odds ratios (OR) and 95% confidence intervals (CI) for the association between OBS and TD prevalence. After adjusting for potential confounders, a negative linear association was observed between OBS and TD prevalence (OR = 0.98, 95% CI 0.97–1.00). Participants in the highest OBS tertile had lower odds of TD compared to those in the lowest tertile (OR = 0.92, 95% CI 0.69–1.21). Lifestyle components of OBS were significantly associated with lower TD prevalence (OR = 0.85, 95% CI 0.81–0.90). Furthermore, least absolute shrinkage and selection operator regression identified key OBS components most strongly associated with TD, with physical activity exerting the greatest influence. A predictive nomogram model incorporating these components demonstrated a discriminatory power with an area under the curve of 0.744 (95% CI 72.4–76.4%). In conclusion, this study demonstrates an inverse association between OBS and TD prevalence, suggesting a potential role of oxidative balance in testosterone regulation among US males.

Nov 28, 2023 | academicradiology.org | Jun Zhang |Liang Xia |Jun Tang |Jianguo Xia |Yongkang Liu |Weixiao Zhang | +5 more

To construct and validate a deep learning radiomics (DLR) model based on X-ray images for predicting and distinguishing acute and chronic osteoporotic vertebral fractures (OVFs). A total of 942 cases (1076 vertebral bodies) with both vertebral X-ray examination and MRI scans were included in this study from three hospitals.

Oct 24, 2023 | dovepress.com | Man Sun |Huan Zhang |Jiayi Liu |Jiayi Chen

Back to Journals » International Journal of Nanomedicine » Volume 19 Authors Sun M, Zhang H, Liu J, Chen J, Cui Y, Wang S, Zhang X, Yang Z Received 24 October 2023 Accepted for publication 20 February 2024 Published 6 March 2024 Volume 2024:19 Pages 2241—2264 DOI https://doi.org/10.2147/IJN.S446224 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Kamakhya Misra Man Sun,1 Huan Zhang,1 Jiayi Liu,1 Jiayi Chen,1 Yaxin...

Sep 29, 2023 | biorxiv.org | Jiayi Liu |Tal Ashuach |Fumitaka Inoue |Nadav Ahituv

AbstractThe advent of the perturbation-based massively parallel reporter assays (MPRAs) technique has enabled delineating of the roles of non-coding regulatory elements in orchestrating gene expression. However, computational efforts remain scant to evaluate and establish guidelines for sequence design strategies for perturbation MPRAs. Here, we propose a framework for evaluating and comparing various perturbation strategies for MPRA experiments.

Aug 2, 2023 | researchgate.net | Xiaohui Fan |Jiayi Liu

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