Tao Gong

Nov 29, 2024 | nature.com | Tao Gong

AbstractProteolytic targeting chimera (PROTAC) technology is a protein-blocking technique and induces antitumor effects, with potential advantages. However, its effect is limited by insufficient distribution and accumulation in tumors. Herein, a transformable nanomedicine (dBET6@CFMPD) with mitochondrial targeting capacity is designed and constructed to combine PROTAC with photodynamic therapy (PDT).

Sep 5, 2023 | science.org | Ga-Yeon Son |Zhengyi Li |Annalisa M. VanHook |Tao Gong

Published In Science SignalingVolume 16 | Issue 801September 2023Article versionsSubmission historyReceived: 9 December 2022Accepted: 11 August 2023PermissionsRequest permissions for this article. AcknowledgmentsWe thank D. Yi from the Third Military Medical University for providing guidance on statistical analysis methods. We thank the scientists from PTM BioLab (Hangzhou) for the assistance of proteomic analysis.