Ga-Yeon Son

Dec 18, 2024 | science.org | Yin-Hu Wang |Wenyi Li |Maxwell McDermott |Ga-Yeon Son |George Maiti |Fang Zhou | +9 more

Research ArticleAUTOIMMUNITY Access the full articleView all access options to continue reading this article. Supplementary MaterialsMaterials and MethodsFigs. S1 to S32Tables S1 to S4MDAR Reproducibility ChecklistREFERENCES AND NOTES1C. P. Mavragani, H. M. Moutsopoulos, Sjögren’s syndrome. Annu. Rev. Pathol. 9, 273–285 (2014). 2P. Brito-Zerón, C. Baldini, H. Bootsma, S. J. Bowman, R. Jonsson, X. Mariette, K. Sivils, E. Theander, A. Tzioufas, M. Ramos-Casals, Sjögren syndrome. Nat. Rev. Dis. Primers 2, 16047 (2016). 3X.

Jan 24, 2024 | biorxiv.org | Yin-Hu Wang |Wenyi Li |Ga-Yeon Son |Maxwell McDermott

AbstractObjectives. Sjögren's Disease (SjD) is an autoimmune disorder characterized by progressive dysfunction, inflammation and destruction of salivary and lacrimal glands, and by extraglandular manifestations. Its etiology and pathophysiology remain incompletely understood, though a role for autoreactive B cells has been considered key. Here, we investigated the role of effector and regulatory T cells in the pathogenesis of SjD. Methods.

Sep 5, 2023 | science.org | Ga-Yeon Son |Zhengyi Li |Annalisa M. VanHook |Tao Gong

Published In Science SignalingVolume 16 | Issue 801September 2023Article versionsSubmission historyReceived: 9 December 2022Accepted: 11 August 2023PermissionsRequest permissions for this article. AcknowledgmentsWe thank D. Yi from the Third Military Medical University for providing guidance on statistical analysis methods. We thank the scientists from PTM BioLab (Hangzhou) for the assistance of proteomic analysis.

Sep 5, 2023 | science.org | Ga-Yeon Son |Zhengyi Li |Annalisa M. VanHook |Nguyen Tu

Published In Science SignalingVolume 16 | Issue 801September 2023Article versionsSubmission historyReceived: 23 November 2022Accepted: 15 August 2023PermissionsRequest permissions for this article. AcknowledgmentsWe would like to thank B. Schmidt (NYU) for discussions and for sharing resources available in his laboratory. ORAI1 shRNAs were obtained from S. Feske at NYU School of Medicine. Human ORAI1 (pCAGGS-IRES-GFP) and STIM1 (pCAGGS-IRES-RFP) were obtained from B. A.

Sep 5, 2023 | science.org | Ga-Yeon Son |Zhengyi Li |Annalisa M. VanHook

Editors' ChoiceDEVELOPMENTAL BIOLOGYThe breaking of left-right symmetry in many vertebrate embryos depends on the clockwise beating of cilia within a left-right organizer located on the midline. In mice, the organizer is known as the ventral node and consists of central pit cells bearing motile cilia surrounded by crown cells bearing nonmotile cilia.