Thorsten Stiewe

Jan 9, 2025 | nature.com | Philipp Münick |Alexander Strubel |Dimitrios-Ilias Balourdas |Julianne Funk |Marcel Tuppi |Busra Yuksel | +4 more

AbstractInfection of cells with high-risk strains of the human papillomavirus (HPV) causes cancer in various types of epithelial tissue. HPV infections are responsible for ~4.5% of all cancers worldwide. Tumorigenesis is based on the inactivation of key cellular control mechanisms by the viral proteins E6 and E7. The HPV E6 protein interacts with the cellular E3 ligase E6AP, and this complex binds to the p53 DNA-binding domain, which results in degradation of p53.

Oct 22, 2024 | nature.com | Andreas C. Joerger |Thorsten Stiewe

AbstractThe transcription factor p53 plays a key role in the cellular defense against cancer development. It is inactivated in virtually every tumor, and in every second tumor this inactivation is due to a mutation in the TP53 gene. In this perspective, we show that this diverse mutational spectrum is unique among all other cancer-associated proteins and discuss what drives the selection of TP53 mutations in cancer.

Jun 12, 2024 | nature.com | Jan Budczies |Eva Romanovsky |Olaf Neumann |Thorsten Stiewe |Daniel Kazdal |Petros Christopoulos

AbstractPredictive biomarkers in use for immunotherapy in advanced non-small cell lung cancer are of limited sensitivity and specificity. We analysed the potential of activating KRAS and pathogenic TP53 mutations to provide additional predictive information. The study cohort included 713 consecutive immunotherapy patients with advanced lung adenocarcinomas, negative for actionable genetic alterations.

Feb 22, 2024 | nature.com | Andreas Weigert |Friedrich Grimminger |Werner Seeger |Thorsten Stiewe |Soni S. Pullamsetti

AbstractDual-specificity phosphatase 8 (DUSP8) plays an important role as a selective c-Jun N-terminal kinase (JNK) phosphatase in mitogen-activated protein kinase (MAPK) signaling. In this study, we found that DUSP8 is silenced by miR-147b in patients with lung adenocarcinoma (LUAD), which correlates with poor overall survival.

Nov 7, 2023 | mdpi.com | Stella Logotheti |Thorsten Stiewe |Alexandros G. Georgakilas

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