Werner Seeger

Feb 22, 2024 | nature.com | Andreas Weigert |Friedrich Grimminger |Werner Seeger |Thorsten Stiewe |Soni S. Pullamsetti

AbstractDual-specificity phosphatase 8 (DUSP8) plays an important role as a selective c-Jun N-terminal kinase (JNK) phosphatase in mitogen-activated protein kinase (MAPK) signaling. In this study, we found that DUSP8 is silenced by miR-147b in patients with lung adenocarcinoma (LUAD), which correlates with poor overall survival.

Sep 28, 2023 | nature.com | Prakash Chelladurai |Samer Alabed |Carsten Kuenne |Werner Seeger |Mario Looso |Allan Lawrie | +1 more

AbstractRight ventricular (RV) function is critical to prognosis in all forms of pulmonary hypertension. Here we perform molecular phenotyping of RV remodeling by transcriptome analysis of RV tissue obtained from 40 individuals, and two animal models of RV dysfunction of both sexes.