Tianjin Branch

Jul 29, 2024 | trialsjournal.biomedcentral.com | Tianjin Branch

Methods/designThis is a 12-month, randomized, parallel-controlled, single-center clinical trial enrolling children aged 8–12 years with myopia as subjects. The main purpose of this clinical trial is to evaluate the efficacy and safety of combination therapy of RLRL and DIMS spectacle lenses in slowing myopia progression in children. This clinical trial will be conducted at a tertiary hospital, Tianjin Medical University Eye Hospital.

Jan 18, 2024 | onlinelibrary.wiley.com | Liming Wang |Tianjin Branch |Zhao Xu |Yaru Hong

1 INTRODUCTION Acute primary angle closure (APAC) is an ophthalmic emergency comprising complaints of sudden headache, nausea or vomiting, eye pain and redness and blurry vision. Eyes with APAC usually have a narrow anterior chamber angle and forward bowing of the peripheral iris.

Nov 17, 2023 | diabetesjournals.org | Tianjin Branch

Endothelial cells (EC) play essential roles in retinal vascular homeostasis. This study aimed to characterize retinal EC heterogeneity and functional diversity using single-cell RNA sequencing. Systematic analysis of cellular compositions and cell-cell interaction networks identified a unique EC cluster with high inflammatory gene expression in diabetic retina; sphingolipid metabolism is a prominent aspect correlated with changes in retinal function.

Nov 17, 2023 | diabetesjournals.org | Tianjin Branch

Endothelial cells (EC) play essential roles in retinal vascular homeostasis. This study aimed to characterize retinal EC heterogeneity and functional diversity using single-cell RNA sequencing. Systematic analysis of cellular compositions and cell-cell interaction networks identified a unique EC cluster with high inflammatory gene expression in diabetic retina; sphingolipid metabolism is a prominent aspect correlated with changes in retinal function.

Nov 8, 2023 | diabetesjournals.org | Tianjin Branch

Enhancing the development and thermogenesis in brown and beige fat represents a potential treatment for obesity. In the present study, we show that Foxj3 expression in fat is stimulated by cold exposure and a β-adrenergic agonist. Adipose-specific Foxj3 knockout impairs the thermogenic function of brown fat, leading to morphological whitening of brown fat and obesity. Adipose Foxj3-deficient mice display increased fasting blood glucose levels and hepatic steatosis on a chow diet.