Timothy Durham

1 month ago | biorxiv.org | Rahul Gupta |Timothy Durham |Grant Chau |Mesbah Uddin

AbstractOne of the strongest signatures of aging is an accumulation of mutant mitochondrial DNA (mtDNA) heteroplasmy. Here we investigate the mechanism underlying this phenomenon by calling mtDNA sequence, abundance, and heteroplasmic variation in human blood using whole genome sequences from ~750,000 individuals.

Nov 1, 2024 | northamptonchron.co.uk | Timothy Durham

Watch more of our videos on ShotsTV.com and on Freeview 262 or Freely 565Visit Shots! nowThe Autumn Budget announced today marks a significant turning point for Northampton, delivering targeted investment in our public services, infrastructure, and local economy, says Mike Reader, Member of Parliament for Northampton South. The Budget includes a major boost for the NHS, with £22.6 billion additional funding by 2025-26 to deliver 40,000 more appointments every week.

Oct 3, 2024 | northamptonchron.co.uk | Timothy Durham

Watch more of our videos on ShotsTV.com and on Freeview 262 or Freely 565Visit Shots! nowNorthampton South MP Mike Reader is encouraging permanent residents of Northampton holiday parks to apply for a dedicated Warm Home Discount scheme operated by Charis. Payments of £150 are available to eligible Park Home residents, such as those who live at Billing Aquadrome, who do not have a direct relationship with an electricity supplier and instead pay the site owners for their electricity.

Jun 3, 2024 | nature.com | Rahul Gupta |Masahiro Kanai |Timothy Durham |Anna V. Kotrys |Wei Zhou |Konrad J Karczewski | +1 more

Correction to: Nature https://doi.org/10.1038/s41586-023-06426-5Published online 16 August 2023When performing a genome-wide association study (GWAS), the choice of which allele (reference vs. alternate) is considered the “effect allele” is arbitrary. In our computations, we chose the reference allele. For a small subset of our results, the effect sizes were erroneously attributed to the alternate allele.

Apr 24, 2024 | nature.com | Anna V. Kotrys |Timothy Durham

AbstractHeteroplasmy occurs when wild-type and mutant mitochondrial DNA (mtDNA) molecules co-exist in single cells1. Heteroplasmy levels change dynamically in development, disease and ageing2,3, but it is unclear whether these shifts are caused by selection or drift, and whether they occur at the level of cells or intracellularly.