Mesbah Uddin

1 month ago | biorxiv.org | Rahul Gupta |Timothy Durham |Grant Chau |Mesbah Uddin

AbstractOne of the strongest signatures of aging is an accumulation of mutant mitochondrial DNA (mtDNA) heteroplasmy. Here we investigate the mechanism underlying this phenomenon by calling mtDNA sequence, abundance, and heteroplasmic variation in human blood using whole genome sequences from ~750,000 individuals.

Oct 28, 2024 | digitalcommons.library.tmc.edu | Seyedmohammad Saadatagah |Mesbah Uddin |Lachelle D. Weeks |Abhishek Niroula

IMPORTANCE: Clonal hematopoiesis (CH) with acquired pathogenic variants in myeloid leukemia driver genes is common in older adults but of unknown prognostic value. OBJECTIVE: To investigate the prevalence of CH and the utility of the CH risk score (CHRS) in estimating all-cause and disease-specific mortality in older adults with CH.

Mar 28, 2024 | nature.com | Zhi Yu |Mesbah Uddin

AbstractGermline variation and somatic mutation are intricately connected and together shape human traits and disease risks. Germline variants are present from conception, but they vary between individuals and accumulate over generations. By contrast, somatic mutations accumulate throughout life in a mosaic manner within an individual due to intrinsic and extrinsic sources of mutations and selection pressures acting on cells.

Jan 17, 2024 | jamanetwork.com | Seyedmohammad Saadatagah |Mesbah Uddin |Lachelle D. Weeks

Key PointsQuestion  Is the clonal hematopoiesis (CH) risk score associated with all-cause and disease-specific mortality in older adults with CH? Findings  In this cohort study that included 3871 individuals without hematologic malignant neoplasms at baseline, 24.2% had CH.