Mesbah Uddin

Oct 28, 2024 | digitalcommons.library.tmc.edu | Seyedmohammad Saadatagah |Mesbah Uddin |Lachelle D. Weeks |Abhishek Niroula

IMPORTANCE: Clonal hematopoiesis (CH) with acquired pathogenic variants in myeloid leukemia driver genes is common in older adults but of unknown prognostic value. OBJECTIVE: To investigate the prevalence of CH and the utility of the CH risk score (CHRS) in estimating all-cause and disease-specific mortality in older adults with CH.

Mar 28, 2024 | nature.com | Zhi Yu |Mesbah Uddin

AbstractGermline variation and somatic mutation are intricately connected and together shape human traits and disease risks. Germline variants are present from conception, but they vary between individuals and accumulate over generations. By contrast, somatic mutations accumulate throughout life in a mosaic manner within an individual due to intrinsic and extrinsic sources of mutations and selection pressures acting on cells.

Jan 17, 2024 | jamanetwork.com | Seyedmohammad Saadatagah |Mesbah Uddin |Lachelle D. Weeks

Key PointsQuestion  Is the clonal hematopoiesis (CH) risk score associated with all-cause and disease-specific mortality in older adults with CH? Findings  In this cohort study that included 3871 individuals without hematologic malignant neoplasms at baseline, 24.2% had CH.

May 16, 2023 | arxiv.org | Mesbah Uddin

In this paper, we present a machine learning-based data generator framework tailored to aid researchers who utilize simulations to examine various physical systems or processes. High computational costs and the resulting limited data often pose significant challenges to gaining insights into these systems or processes.

Apr 12, 2023 | nature.com | Joshua Weinstock |Bala Bharathi Burugula |Mesbah Uddin |Bence Daniel |Shaneice Mitchell |Cecelia Laurie | +41 more

AbstractMutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells (HSCs), leading to clonal haematopoiesis1. These lesions are precursors for blood cancers2,3,4,5,6, but the basis of their fitness advantage remains largely unknown, partly owing to a paucity of large cohorts in which the clonal expansion rate has been assessed by longitudinal sampling.