Timothy Webb

Nov 6, 2024 | digitalcommons.library.tmc.edu | Guanxing Chen |Qin Li |Timothy Webb |Jiusheng Yan

Publication Date6-5-2023JournalThe Journal of General PhysiologyAbstractThe large-conductance, Ca2+-, and voltage-activated K+ (BK) channel consists of the pore-forming α (BKα) subunit and regulatory β and γ subunits. The γ1-3 subunits facilitate BK channel activation by shifting the voltage-dependence of channel activation toward the hyperpolarization direction by about 50-150 mV in the absence of Ca2+.