
Ting Yu
Articles
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Dec 10, 2024 |
nature.com | Kejia Li |Shijie Chen |Keyun Wang |Yan Wang |Yuying Ye |Zheng Fang | +14 more
By using a limited-proteolysis strategy that employs a large amount of trypsin to generate peptides directly from native proteins, we found that ligand-induced protein local stability shifts can be sensitively detected on a proteome-wide scale. This enabled us to develop the peptide-centric local stability assay, a modification-free approach that achieves unprecedented sensitivity in proteome-wide target identification and binding-region determination. We demonstrate the broad applications of the peptide-centric local stability assay by investigating interactions across various biological contexts. The peptide-centric local stability assay (PELSA) can be used to determine ligand-binding targets and binding regions on a proteome-wide scale with high sensitivity.
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Nov 29, 2024 |
ozbargain.com.au | Ting Yu
AssociatedTing Yu on 29/11/2024 - 17:23 curaprox.com.au (8 clicks)Last edited 29/11/2024 - 17:32 by 1 other user Christmas is just around the corner—what better gift than a healthy smile for your loved ones? Use code CHRISTMAS20 to enjoy 20% off when you spend $150 or more on Hydrosonic toothbrushes, manual toothbrushes, toothpastes, baby and kids' oral care products.
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Sep 24, 2024 |
medium.com | Ting Yu
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Sep 22, 2024 |
arxiv.org | Ting Yu
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Sep 6, 2024 |
mdpi.com | Yu Li |Dan Wu |Ting Yu |Bing Liu
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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