Ting Zhu

Dec 24, 2024 | nature.com | Ting Zhu |Yao Hu |Yang Cao |Jia Xu |Heng-Qing Ye |Wei Zhang | +1 more

Depression is a heterogeneous and complex psychological syndrome with highly variable manifestations, which poses difficulties for treatment and prognosis. Depression patients are prone to developing various comorbidities, which stem from different pathophysiological mechanisms, remaining largely understudied. The current study focused on identifying comorbidity-specific phenotypes, and whether these clustered phenotypes are associated with different treatment patterns, clinical manifestations, physiological characteristics, and prognosis. We have conducted a 10-year retrospective observational cohort study using electronic medical records (EMR) for 11,818 patients diagnosed with depression and hospitalized at a large academic medical center in Chengdu, China. K-means clustering and visualization methods were performed to identify phenotypic categories. The association between phenotypic categories and clinical outcomes was evaluated using adjusted Cox proportional hazards model. We classified patients with depression into five stable phenotypic categories, including 15 statistically driven clusters in the discovery cohort (n = 9925) and the validation cohort (n = 1893), respectively. The categories include: (Category A) the lowest incidence of comorbidity, with prominent suicide, psychotic, and somatic symptoms (n = 3493/9925); (Category B) moderate comorbidity rate, with prominent anhedonia and anxious symptoms (n = 1795/9925); (Category C) the highest incidence of comorbidity of endocrine/metabolic and digestive system diseases (n = 1702/9925); (Category D) the highest incidence of comorbidity of neurological, mental and behavioral diseases (n = 881/9925); (Category E) other diseases comorbid with depression (n = 2054/9925). Patients in Category E had the lowest risk of psychiatric rehospitalization within 60-day follow-up, followed by Category C (HR, 1.57; 95% CI, 1.07–2.30), Category B (HR, 1.61; 95% CI, 1.10–2.40), Category A (HR, 1.82; 95% CI, 1.28–2.60), and Category D (HR, 2.38; 95% CI, 1.59–3.60) with P < 0.05, after adjustment for comorbidities, medications, and age. Regarding other longer observation windows (90-day, 180-day and 365-day), patients in Category D showed the highest rehospitalization risk all the time while there were notable shifts in rankings observed for Categories A, B and C over time. The results indicate that the higher the severity of mental illness in patients with five phenotypic categories, the greater the risk of rehospitalization. These phenotypes are associated with various pathways, including the cardiometabolic system, chronic inflammation, digestive system, neurological system, and mental and behavioral disorders. These pathways play a crucial role in connecting depression with other psychiatric and somatic diseases. The identified phenotypes exhibit notable distinctions in terms of comorbidity patterns, symptomology, biological characteristics, treatment approaches, and clinical outcomes.

Dec 19, 2024 | virologyj.biomedcentral.com | Hong-Mei Chen |Ting Zhu |Yu Huang |Qi-Zhang Liang |Rong-Chang Liu |Qiu-Ling Fu | +3 more

Muscovy duck parvovirus (MDPV), duck adenovirus type 3 (DAdV-3), adenovirus type 4 (AdV-4), duck plague virus (DPV), duck hepatitis virus (DHV), and duck tembusu virus (DTMUV) were retrieved from clinical samples within Fujian Province and are being conserved by the Institute of Animal Science and Veterinary Medicine of the Fujian Academy of Agricultural Sciences. RNA and DNA extraction was performed using the Animal Total RNA/DNA Isolation Kit from TianLong (Suzhou, China).

Oct 30, 2024 | dx.doi.org | Jing Jing Liu |Zi-Hao Liao |Ting Zhu |Jin Wu

Mar 11, 2024 | pubs.rsc.org | Li Ping Liu |Ting Zhu |Jiaqi Li |Can Wang

Strategic Structure Modulation of Novel Quinoxaline-Derived Liquid Organic Hydrogen Carriers for Enhanced Dehydrogenation Kinetics This study introduces novel Liquid Organic Hydrogen Carriers (LOHCs) derived from quinoxaline. It shows that strategically incorporating N atoms and methyl groups markedly improves hydrogen release kinetics.

Oct 19, 2023 | pubs.rsc.org | Ting Zhu |Biomedical Engineering |Nanyang Technological |Jun Chen

Correction: Shape-controlled synthesis of porous Co3O4 nanostructures for application in supercapacitors Correction for ‘Shape-controlled synthesis of porous Co3O4 nanostructures for application in supercapacitors’ by Ting Zhu et al., J. Mater. Chem., 2010, 20, 7015–7020, https://doi.org/10.1039/C0JM00867B. This article is Open Access This article has not yet been cited.