Tomokazu Sumida

Aug 28, 2024 | science.org | Loretah Chibaya |Ying Liu |Jie Ma |Tomokazu Sumida

Editor’s summaryRegulatory T cells (Tregs) are known to be dysfunctional in autoimmune diseases, but the cause of this dysfunction has not been fully elucidated. Here, Sumida et al.

Feb 19, 2024 | nature.com | Tomokazu Sumida |David A. Hafler

AbstractThe discovery of FOXP3+ regulatory T (Treg) cells as a distinct cell lineage with a central role in regulating immune responses provided a deeper understanding of self-tolerance. The transcription factor FOXP3 serves a key role in Treg cell lineage determination and maintenance, but is not sufficient to enable the full potential of Treg cell suppression, indicating that other factors orchestrate the fine-tuning of Treg cell function.