David A. Hafler

2 months ago | neurologylive.com | David A. Hafler |Isabella Ciccone

WATCH TIME: 5 minutes“We know that for every clinical event, there are 10 MRI events. Why wait for a clinical event for a pathologic diagnosis? The McDonald Diagnostic Criteria, established in 2001 and last revised in 2017, serves as a key resource for neurologists to enhance the accuracy and efficiency of diagnosing multiple sclerosis (MS).

Jan 16, 2025 | jci.org | Yoshiaki Yasumizu |David A. Hafler |Michael Kramer |Benedetta Terziroli Beretta-Piccoli

CommentaryOpen Access | 10.1172/JCI188538 Published inVolume 135, Issue 2onJanuary 16, 2025J Clin Invest. 2025;135(2):e188538. https://doi.org/10.1172/JCI188538. © 2025 Yasumizu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Nov 17, 2024 | neurologylive.com | David A. Hafler |Isabella Ciccone

CommentaryVideoNovember 17, 2024Author(s):,Fact checked by:The William S. and Lois Stiles Edgerly Professor of Neurology at Yale School of Medicine talked about the ongoing evolution of multiple sclerosis diagnostic criteria and the importance of comprehensive testing to guide early intervention and improve outcomes.

Nov 13, 2024 | neurologylive.com | David A. Hafler |Isabella Ciccone

The McDonald Diagnostic Criteria, initially developed in 2001 and last updated in 2017, provides neurologists with guidelines to improve the accuracy and timeliness of multiple sclerosis (MS) diagnoses. Since 2021, an expert committee has worked on further updates to reflect new knowledge about MS, aiming to help clinicians identify the disease earlier for better patient outcomes.

May 13, 2024 | nature.com | Matthew Lincoln |Christiane Gasperi |David van Heel |Sebo Withoff |Iris H. Jonkers |Leonid Padyukov | +6 more

AbstractAutoimmune and inflammatory diseases are polygenic disorders of the immune system. Many genomic loci harbor risk alleles for several diseases, but the limited resolution of genetic mapping prevents determining whether the same allele is responsible, indicating a shared underlying mechanism. Here, using a collection of 129,058 cases and controls across 6 diseases, we show that ~40% of overlapping associations are due to the same allele.