Tore Bleckwehl

Dec 4, 2024 | nature.com | Konrad Hoeft |Tore Bleckwehl |Robert Meyer |Turgay Saritas |Ingo Kurth |Sikander Hayat

AbstractSingle cell RNA sequencing has provided unprecedented insights into the molecular cues and cellular heterogeneity underlying human disease. However, the high costs and complexity of single cell methods remain a major obstacle for generating large-scale human cohorts.

Dec 4, 2024 | nature.com | Konrad Hoeft |Tore Bleckwehl |Robert Meyer |Turgay Saritas |Ingo Kurth |Sikander Hayat

AbstractSingle cell RNA sequencing has provided unprecedented insights into the molecular cues and cellular heterogeneity underlying human disease. However, the high costs and complexity of single cell methods remain a major obstacle for generating large-scale human cohorts.

Oct 23, 2024 | nature.com | Junedh Amrute |Tracy M. Yamawaki |Sikander Hayat |Andrea Bredemeyer |In-Hyuk Jung |Andrew Koenig | +9 more

AbstractInflammation and tissue fibrosis co-exist and are causally linked to organ dysfunction1,2. However, the molecular mechanisms driving immune–fibroblast cell communication in human cardiac disease remain unexplored and there are at present no approved treatments that directly target cardiac fibrosis3,4. Here we performed multiomic single-cell gene expression, epitope mapping and chromatin accessibility profiling in 45 healthy donor, acutely infarcted and chronically failing human hearts.