Tsunekazu Mizushima

Jul 13, 2024 | ejso.com | Mitsuru Ishizuka |Norisuke Shibuya |Hiroyuki Hachiya |Yusuke Nishi |Takayuki Shiraki |Takatsugu Matsumoto | +8 more

Abstract To investigate whether robotic surgery (RS) decreases the risk of circumferential resection margin (CRM) positivity compared with conventional laparoscopic surgery (LS) in patients with rectal cancer (RC) undergoing mesorectal excision (ME). Although it is well known that CRM positivity affects postoperative outcomes in patients with RC undergoing ME, few studies have investigated whether RS is superior to conventional LS for the risk of CRM positivity.

Feb 28, 2024 | iv.iiarjournals.org | Ryota Mori |Norikatsu Miyoshi |Shiki Fujino |Tsunekazu Mizushima

Key Words:Adipose derived stem cellanal sphincter injuryintestinal incontinenceARSdefecation functionIntestinal incontinence is a common condition defined as the uncontrolled passage of feces or gas for at least one month and has a negative impact on quality of life (1). Although the main causes of defecation problems have been age-related weakness of defecation-related muscle groups, the number of patients who develop the condition after surgery has increased.

Nov 23, 2023 | nature.com | Shiki Fujino |Norikatsu Miyoshi |Jun Koseki |Tsunekazu Mizushima

AbstractCirculating tumor cells (CTCs) play an important role in metastasis and recurrence. However, which cells comprise the complex tumor lineages in recurrence and are key in metastasis are unknown in colorectal cancer (CRC). CRC with high expression of POU5F1 has a poor prognosis with a high incidence of liver metastatic recurrence.

Mar 3, 2023 | nature.com | Daisuke Okuzaki |Hidekazu Takahashi |Tsunekazu Mizushima

Study design and patientsThis study evaluated 126 patients with CRC who underwent surgical resection from 2012 to 2013 for immunohistochemistry staining and overall survival (OS) and recurrence-free survival (RFS) rate. Freshly resected CRC tissues and adjacent normal tissues were obtained immediately after surgical resection in 2020.