Tuhin Das

Sep 13, 2024 | chemistry-europe.onlinelibrary.wiley.com | Tuhin Das |Eva F. Hayball |Alix C. Harlington |Biomedical Science

Introduction Cytochrome P450 enzymes (CYPs) are a group of heme-thiolate enzymes that catalyse the regio- and stereo-selective oxidation of carbon-hydrogen (C−H) bonds in organic compounds.1 The enzymes participate in a wide range of chemical reactions including; decarboxylation, epoxidation, desaturation, dealkylation, and sulfoxidation.2 They are therefore of significant interest as biocatalysts to simplify synthetic routes involving selective late-stage functionalisation of complex...

Jul 14, 2024 | biorxiv.org | Alix C. Harlington |Tuhin Das |Keith E. Shearwin |Stephen Bell

AbstractThe O-demethylation of lignin aromatics is a rate-limiting step in their bioconversion to high-value compounds. A recently discovered cytochrome P450 enzyme SyoA was found to demethylate the sinapyl alcohol-derived (S-lignin) aromatic syringol. In this work, we solved high-resolution X-ray crystal structures of SyoA in the substrate-free and substrate-bound states and evaluate the demethylation of para-substituted S-lignin aromatics via the monooxygenase pathway and peroxide shunt pathway.

Mar 20, 2024 | arxiv.org | Tuhin Das |Fabio Pizzati |Philip H.S. Torr |Adel Bibi

arXiv:2403.13808 (cs) Download PDF HTML (experimental) Comments: Subjects: Computer Vision and Pattern Recognition (cs.CV); Artificial Intelligence (cs.AI); Machine Learning (cs.LG) Cite as: arXiv:2403.13808 [cs.CV] (or arXiv:2403.13808v1 [cs.CV] for this version) Submission history From: Fabio Pizzati [ view email] [v1] Wed, 20 Mar 2024 17:59:58 UTC (2,094 KB) Bibliographic Tools Bibliographic Explorer Toggle Bibliographic Explorer () Litmaps Toggle Litmaps (What is Litmaps?) scite.ai Toggle...

Mar 3, 2024 | tuhindas1.medium.com | Tuhin Das

Over the past few years, there have been transformational changes that are quickly reshaping industries and challenging traditional business models. The ability of AI to process vast amounts of data, learn from patterns and do complex tasks, there is no limit to what AI can do. This article touches on some key areas where AI is revolutionizing everyday human experiences.

Feb 2, 2024 | publicsource.org | Tuhin Das |Natasha Vicens

After a long evening spent with other dissenting writers in 2001, I hailed a rickshaw to take me home. Previously, a ride late at night in my hometown, Barishal, Bangladesh, would not have worried me, but this was an anxious time. A few months prior, two political parties, the Jamaat-e-Islami and Bangladesh Nationalist Party, unexpectedly formed a coalition government around Islamist, nationalist principles.