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1 week ago | 
genengnews.com | Corinna Singleman |Alex Philippidis |Uduak Grace Thomas |Fay Y. Lin
Credit: Just_Super / iStock / Getty Images Plus
BIO 2025 is off and running. GEN editors discuss the size and scope of the bustling conference hall and share excitement about the week’s talks and panels. News from BIO includes the announcement of Lilly’s acquisition of Verve Therapeutics. Editors discuss the implications of industry-backed therapeutics amid cautious investors and public sentiment.
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1 week ago | 
genengnews.com | Uduak Grace Thomas
A view of some of the exhibitors in attendance at BIO 2025 [Uduak Thomas]
At this year’s BIO International Convention, held June 16–19 in Boston, MA, two companies, 64x Bio and Fauna Bio, introduced new products aimed at improving therapy delivery and identifying novel drug targets for a range of human diseases, respectively. For its part, 64x Bio launched AAV Apex suite, a product designed to address bottlenecks in gene therapy manufacturing.
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2 weeks ago | 
genengnews.com | Uduak Grace Thomas
Home Topics OMICs Proteomics Partnerships Move Multiomics from Theory to Practice Credit: Thom Leach / Science Photo Library
David PeoplesCFO, CBOUltima GenomicsMultiomics is in vogue and several sequencing companies have taken notice.
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2 weeks ago | 
genengnews.com | Uduak Grace Thomas
Credit: Alllex
Using single-nuclei RNA sequencing (snRNA-seq), scientists from Mass General Brigham, SUNY Upstate Medical University, and elsewhere have identified specific brain cell types in the hippocampus that respond best to physical exercise in mouse models of Alzheimer’s disease. The findings help to elucidate the connection between exercise and brain health, and offer fresh insights into potential treatment strategies for people living with Alzheimer’s.
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2 weeks ago | 
genengnews.com | Uduak Grace Thomas
Source: selvanegra / Getty Images
After studying 140,000 versions of the Aβ42 peptide, scientists identified some of the earliest molecular interactions that drive the formation of harmful amyloid protein aggregates found in Alzheimer’s disease cases.
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2 weeks ago | 
genengnews.com | Uduak Grace Thomas
Credit: Andriy Onufriyenko/Getty Images
Children living with multiple sclerosis (MS) show signs of accelerated biological aging, even in their teenage years.
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3 weeks ago | 
genengnews.com | Alex Philippidis |Fay Y. Lin |Uduak Grace Thomas |Corinna Singleman
A gene therapy clinical trial for Danon disease run by Rocket Pharmaceuticals has been suspended following the death of a patient. MIT and Recursion have released Boltz-2, an open-source tool that predicts molecular binding affinity at newfound speed and accuracy, aiming to democratize commercial drug discovery. Intellia Therapeutics saw its stock nosedive late last week after a patient in its Phase III trial of the CRISPR-based therapy experienced non-lethal liver toxicity.
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3 weeks ago | 
genengnews.com | Uduak Grace Thomas
Scientists from the University of California, San Diego (UC San Diego), have published data from a study that tested the effects of a gene therapy for Alzheimer’s disease (AD) dubbed AAV9-Synapsin-promoted Cav-1 (SynCav1) in mice. The results indicate that the therapy could be an effective way to protect the brain from disease-related damage and preserve cognitive function.
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3 weeks ago | 
genengnews.com | Uduak Grace Thomas
Stanford University researchers are using machine learning algorithms to modify human proteins with an eye toward improving the efficacy and safety of targeted cell and gene therapies by reducing the risks of an adverse immune response.
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3 weeks ago | 
genengnews.com | Uduak Grace Thomas
Home News Diminished Stress Response in Aging Neurons Linked to Neurodegeneration Credit: cherezoff / iStock / Getty Images Plus Credit: cherezoff / iStock / Getty Images Plus
As people age, their risk of developing neurodegenerative disorders like dementia, Alzheimer’s disease, and Parkinson’s disease increases. A new study from scientists at the University of California, San Diego (UCSD), helps elucidate some of the molecular mechanisms behind why brain cells deteriorate with age.
