UGMLC Giessen Biobank

Sep 23, 2024 | respiratory-research.biomedcentral.com | Mohammad Rashedul |Justus Liebig |Eberhard Karls |UGMLC Giessen Biobank

The fibrosis marker collagen type I (COL1) and myofibroblast marker α-smooth muscle actin (α-SMA) were first assessed in lung biopsy samples from control and IPF patients. Lung tissues from IPF patients showed comparatively higher levels of COL1 and α-SMA than those from control subjects (Fig. 1A). Although increased mRNA levels of COL1A1 and ACTA2 were detected in cultured lung fibroblasts from IPF compared to control patients (Additional file: Fig.