Vincent P. Laudone

Oct 28, 2024 | nature.com | Whitney P. Underwood |Meghan Michalski |Catherine Lee |Gina A. Fickera |Stefan E. Eng |Lydia Y. Liu | +14 more

We developed and evaluated the Digital Platform for Exercise (DPEx): a decentralized, patient-centric approach designed to enhance all aspects of clinical investigation of exercise therapy. DPEx integrated provision of a treadmill with telemedicine and remote biospecimen collection permitting all study procedures to be conducted in patient’s homes. Linked health biodevices enabled high-resolution monitoring of lifestyle and physiological response. Here we describe the rationale and development of DPEx as well as feasibility evaluation in three different cohorts of patients with cancer: a phase 0a development study among three women with post-treatment primary breast cancer; a phase 0b proof-of-concept trial of neoadjuvant exercise therapy in 13 patients with untreated solid tumors; and a phase 1a level-finding trial of neoadjuvant exercise therapy in 53 men with localized prostate cancer. Collectively, our study demonstrates the utility of a fully digital, decentralized approach to conduct clinical trials of exercise therapy in a clinical population.

Jan 2, 2024 | acsjournals.onlinelibrary.wiley.com | Rana R. McKay |Wanling Xie |Xiaoyu Yang |Andres Acosta |Dana E. Rathkopf |Vincent P. Laudone | +9 more

CONFLICT OF INTEREST STATEMENT Rana R.