Gina A. Fickera

Oct 28, 2024 | nature.com | Whitney P. Underwood |Meghan Michalski |Catherine Lee |Gina A. Fickera |Stefan E. Eng |Lydia Y. Liu | +14 more

We developed and evaluated the Digital Platform for Exercise (DPEx): a decentralized, patient-centric approach designed to enhance all aspects of clinical investigation of exercise therapy. DPEx integrated provision of a treadmill with telemedicine and remote biospecimen collection permitting all study procedures to be conducted in patient’s homes. Linked health biodevices enabled high-resolution monitoring of lifestyle and physiological response. Here we describe the rationale and development of DPEx as well as feasibility evaluation in three different cohorts of patients with cancer: a phase 0a development study among three women with post-treatment primary breast cancer; a phase 0b proof-of-concept trial of neoadjuvant exercise therapy in 13 patients with untreated solid tumors; and a phase 1a level-finding trial of neoadjuvant exercise therapy in 53 men with localized prostate cancer. Collectively, our study demonstrates the utility of a fully digital, decentralized approach to conduct clinical trials of exercise therapy in a clinical population.

Sep 19, 2024 | jamanetwork.com | Lee Jones |Chaya Moskowitz |Catherine Lee |Gina A. Fickera

Error in Abstract Neoadjuvant Exercise Therapy in Prostate Cancer Lee W. Jones, PhD; Chaya S. Moskowitz, PhD; Catherine P. Lee, BS, MPH; Gina A. Fickera, BA; Su S. Chun, BA; Meghan G. Michalski, MS; Kurtis Stoeckel, MS; Whitney P. Underwood, BSc; Jessica A. Lavery, MS; Umeshkumar Bhanot, MD, PhD; Irina Linkov, PhD; Chau T. Dang, MD; Behfar Ehdaie, MD; Vincent P. Laudone, MD; James A. Eastham, MD; Anne Collins, RN; Patricia T. Sheerin, RN; Lydia Y. Liu, PhD; Stefan E. Eng, MS; Paul C.