Catherine Lee

Oct 28, 2024 | nature.com | Whitney P. Underwood |Meghan Michalski |Catherine Lee |Gina A. Fickera |Stefan E. Eng |Lydia Y. Liu | +14 more

We developed and evaluated the Digital Platform for Exercise (DPEx): a decentralized, patient-centric approach designed to enhance all aspects of clinical investigation of exercise therapy. DPEx integrated provision of a treadmill with telemedicine and remote biospecimen collection permitting all study procedures to be conducted in patient’s homes. Linked health biodevices enabled high-resolution monitoring of lifestyle and physiological response. Here we describe the rationale and development of DPEx as well as feasibility evaluation in three different cohorts of patients with cancer: a phase 0a development study among three women with post-treatment primary breast cancer; a phase 0b proof-of-concept trial of neoadjuvant exercise therapy in 13 patients with untreated solid tumors; and a phase 1a level-finding trial of neoadjuvant exercise therapy in 53 men with localized prostate cancer. Collectively, our study demonstrates the utility of a fully digital, decentralized approach to conduct clinical trials of exercise therapy in a clinical population.

Oct 17, 2024 | nature.com | Catherine Lee |AKSHAY SHARMA |Taiga Nishihori |Tim Prestidge |Margaret MacMillan |Stephen Spellman | +1 more

AbstractBacterial bloodstream infections (BSI) can be a substantial contributor to complications of GVHD treatment. The aim of this study was to determine the risk for BSI from neutrophil engraftment through day 100 post transplant in patients with acute GVHD (AGVHD) based on organ involvement and severity. Patients (n = 4064) who underwent an allogeneic hematopoietic stem cell transplant (HCT) reported to the CIBMTR registry were analyzed.

Sep 19, 2024 | jamanetwork.com | Lee Jones |Chaya Moskowitz |Catherine Lee |Gina A. Fickera

Error in Abstract Neoadjuvant Exercise Therapy in Prostate Cancer Lee W. Jones, PhD; Chaya S. Moskowitz, PhD; Catherine P. Lee, BS, MPH; Gina A. Fickera, BA; Su S. Chun, BA; Meghan G. Michalski, MS; Kurtis Stoeckel, MS; Whitney P. Underwood, BSc; Jessica A. Lavery, MS; Umeshkumar Bhanot, MD, PhD; Irina Linkov, PhD; Chau T. Dang, MD; Behfar Ehdaie, MD; Vincent P. Laudone, MD; James A. Eastham, MD; Anne Collins, RN; Patricia T. Sheerin, RN; Lydia Y. Liu, PhD; Stefan E. Eng, MS; Paul C.

Nov 27, 2023 | mondaq.com | Catherine Lee

In the case of Siemens Industry Software Inc. (formerly known as Siemens Product Lifecycle Management Software Inc) v Inzign Pte Ltd [2023] SGHC 50 (Siemens v Inzign), Singapore's General Division of the High Court (GDHC) ruled that an organisation may be vicariously liable for its employees' acts of copyright infringement. This decision concerned the unauthorised download and use of a computer software by an Inzign's employee (the Employee).