Weiguo Zou

Oct 15, 2024 | nature.com | Weiguo Zou

AbstractCellular communication network factor 2 (CCN2) is a secreted extracellular matrix-associated protein, and its aberrantly increased expression has been implicated in a diversity of diseases involving pathological processes of fibrosis, chronic inflammation, or tissue injury, which has promoted the evaluation of CCN2 as therapeutic targets for multiple disorders.

Mar 21, 2024 | nature.com | Peng Liao |Weiguo Zou |Peng Ding |Changqing Zhang |Delin Liu |Minghao Zheng | +2 more

AbstractTranscortical vessels (TCVs) provide effective communication between bone marrow vascular system and external circulation. Although osteocytes are in close contact with them, it is not clear whether osteocytes regulate the homeostasis of TCVs. Here, we show that osteocytes maintain the normal network of TCVs by transferring mitochondria to the endothelial cells of TCV. Partial ablation of osteocytes causes TCV regression.