Minghao Zheng

Jun 13, 2024 | nature.com | Peng Ding |Delin Liu |Peng Liao |Minghao Zheng |Youshui Gao |Changqing Zhang | +1 more

AbstractInteractions between osteolineage cells and myeloid cells play important roles in maintaining skeletal homeostasis. Herein, we find that osteolineage cells transfer mitochondria to myeloid cells. Impairment of the transfer of mitochondria by deleting MIRO1 in osteolineage cells leads to increased myeloid cell commitment toward osteoclastic lineage cells and promotes bone resorption.

May 14, 2024 | nature.com | Peng Liao |Minghao Zheng

AbstractMitochondria, with their intricate networks of functions and information processing, are pivotal in both health regulation and disease progression. Particularly, mitochondrial dysfunctions are identified in many common pathologies, including cardiovascular diseases, neurodegeneration, metabolic syndrome, and cancer. However, the multifaceted nature and elusive phenotypic threshold of mitochondrial dysfunction complicate our understanding of their contributions to diseases.

Mar 21, 2024 | nature.com | Peng Liao |Weiguo Zou |Peng Ding |Changqing Zhang |Delin Liu |Minghao Zheng | +2 more

AbstractTranscortical vessels (TCVs) provide effective communication between bone marrow vascular system and external circulation. Although osteocytes are in close contact with them, it is not clear whether osteocytes regulate the homeostasis of TCVs. Here, we show that osteocytes maintain the normal network of TCVs by transferring mitochondria to the endothelial cells of TCV. Partial ablation of osteocytes causes TCV regression.