Weimin Xuan

Aug 11, 2024 | nature.com | Junhong Qin |Miaomiao Chen |Dan Liu |Zexian Liu |Weimin Xuan |Lunzhi Dai | +2 more

AbstractLysine β-hydroxybutyrylation (Kbhb) is a post-translational modification induced by the ketogenic diet (KD), a diet showing therapeutic effects on multiple human diseases. Little is known how cellular processes are regulated by Kbhb. Here we show that protein Kbhb is strongly affected by the KD through a multi-omics analysis of mouse livers.

Aug 11, 2024 | flipboard.com | Junhong Qin |Xinhe Huang |Shengsong Gou |Sitao Zhang |Qian Zhang |Hongyu Chen | +14 more

Natural Sciences1 hour agoZookeepers Say They’ve Solved the Mystery of How a Gibbon Got Pregnant by HerselfVICE • 1hFor two years, a zoo in southern Japan had been puzzled by a mystery: How did Momo, a gibbon kept alone in her cage, get pregnant? The 12-year-old white-handed gibbon lived by herself and was never joined by a companion.

Feb 2, 2024 | chemistry-europe.onlinelibrary.wiley.com | Weimin Xuan |Jun-An Ma

It is of great importance to pinpoint specific residues or sites of a protein in biological contexts to enable desired mechanism of action for small molecules or to precisely control protein function. In this regard, acidic residues including aspartic acid (Asp) and glutamic acid (Glu) hold great potential due to their great prevalence and unique function. To unlock the largely untapped potential, great efforts have been made recently by synthetic chemists, chemical biologists and pharmacologists.