Lunzhi Dai

Aug 11, 2024 | nature.com | Junhong Qin |Miaomiao Chen |Dan Liu |Zexian Liu |Weimin Xuan |Lunzhi Dai | +2 more

AbstractLysine β-hydroxybutyrylation (Kbhb) is a post-translational modification induced by the ketogenic diet (KD), a diet showing therapeutic effects on multiple human diseases. Little is known how cellular processes are regulated by Kbhb. Here we show that protein Kbhb is strongly affected by the KD through a multi-omics analysis of mouse livers.

Aug 11, 2024 | flipboard.com | Junhong Qin |Xinhe Huang |Shengsong Gou |Sitao Zhang |Qian Zhang |Hongyu Chen | +14 more

Natural Sciences1 hour agoZookeepers Say They’ve Solved the Mystery of How a Gibbon Got Pregnant by HerselfVICE • 1hFor two years, a zoo in southern Japan had been puzzled by a mystery: How did Momo, a gibbon kept alone in her cage, get pregnant? The 12-year-old white-handed gibbon lived by herself and was never joined by a companion.

Jul 18, 2024 | nature.com | Di Zhang |Jinjun Gao |Zhijun Zhu |Pankaj K. Singh |Cornelius Rimayi |Carlos Moreno-Yruela | +7 more

AbstractLysine l-lactylation (Kl-la) is a novel protein posttranslational modification (PTM) driven by l-lactate. This PTM has three isomers: Kl-la, N-ε-(carboxyethyl)-lysine (Kce) and d-lactyl-lysine (Kd-la), which are often confused in the context of the Warburg effect and nuclear presence.

Mar 5, 2024 | nature.com | Dan Zhang |Lunzhi Dai |Guangwen Lu |Lu Chen

AbstractPrecise identification and quantification of amino acids is crucial for many biological applications. Here we report a copper(II)-functionalized Mycobacterium smegmatis porin A (MspA) nanopore with the N91H substitution, which enables direct identification of all 20 proteinogenic amino acids when combined with a machine-learning algorithm. The validation accuracy reaches 99.1%, with 30.9% signal recovery.

Nov 25, 2023 | dx.doi.org | Zi Yang |Wei Gan |Lunzhi Dai |He Zhang

RETURN TO ARTICLES ASAPPREVBiological and Medic...Biological and Medical Applications of Materials and InterfacesNEXT Zi Yang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China , Wei Gan Department of Laboratory Medicine, West China Hospital,...