Weston Struwe

Jan 13, 2025 | nature.com | Corinne A. Lutomski |Tarick J. El-Baba |Di Wu |Weston Struwe

AbstractUnderstanding the dynamics of membrane protein–ligand interactions within a native lipid bilayer is a major goal for drug discovery. Typically, cell-based assays are used, however, they are often blind to the effects of protein modifications. In this study, using the archetypal G protein-coupled receptor rhodopsin, we found that the receptor and its effectors can be released directly from retina rod disc membranes using infrared irradiation in a mass spectrometer.