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Oct 23, 2024 | 
arxiv.org | Xiao Feng |R. Michael
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Aug 28, 2024 | 
nature.com | Jiantao Chen |Zhijian Yang |Ranran Zhai |Xiao Feng |Ting Li |Denis Maslov | +25 more
AbstractUnderstanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioural traits and the disease aetiology of neuropsychiatric disorders. Here the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,000 individuals for 184 neuro-related proteins in human plasma. The analysis identified 125 cis-regulatory protein quantitative trait loci (cis-pQTL) and 164 trans-pQTL.
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Aug 4, 2024 | 
mdpi.com | Xiao Feng |Feng Tian |Junfeng Wang |Mingzhang Zhou
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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May 31, 2024 | 
nature.com | Xiao Feng
AbstractNuclear lamin B1 (LMNB1) is a member of the nuclear lamin protein family. LMNB1 can maintain and ensure the stability of nuclear structure and influence the process of cell senescence by regulating chromatin distribution, DNA replication and transcription, gene expression, cell cycle, etc.
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May 31, 2024 | 
nature.com | Xiao Feng |Yanjun Zan |Ting Li |Yang Liu
AbstractGenome-wide association study (GWAS) is a powerful tool to identify genomic loci underlying complex traits. However, the application in natural populations comes with challenges, especially power loss due to population stratification. Here, we introduce a bivariate analysis approach to a GWAS dataset of Arabidopsis thaliana. We demonstrate the efficiency of dual-phenotype analysis to uncover hidden genetic loci masked by population structure via a series of simulations.
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Feb 26, 2024 | 
mdpi.com | Xiao Feng |Tian Tian |Mingzhang Zhou |Haixin Sun
All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.
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Dec 20, 2023 | 
onlinelibrary.wiley.com | Yi Shi |Xiao Feng |Ying Zhang
1 INTRODUCTION Cholangiocarcinoma (CCA) is a rare and aggressive tumour that arises from the biliary tree and is commonly classified according to its anatomic location1-3: intrahepatic (iCCA), perihilar (pCCA), or distal (dCCA) cholangiocarcinoma according to its anatomic location of origin.4 Perihilar CCA and dCCA account for approximately 80% of all CCAs diagnosed in the USA, while iCCA accounts for the remaining 20%.4 The overall incidence of CCA has increased progressively worldwide over...
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Dec 17, 2023 | 
mdpi.com | Xiao Feng |Feng Tian |Mingzhang Zhou |Haixin Sun
All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.
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Nov 29, 2023 | 
onlinelibrary.wiley.com | Xin Chen |Xiao Feng
Aim Ecological forecasting is critical in understanding of ecological responses to climate change and is increasingly used in climate mitigation plans. The forecasts from correlative models can be challenged by model complexity, training collinearity, collinearity shift and novel conditions of predictors that are common during model extrapolation. The individual effect of these four factors has been investigated, but it is still unclear how these four factors interactively affect forecasting.
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Aug 23, 2023 | 
onlinelibrary.wiley.com | Xiao Feng
Aim Ecological niche modelling (ENM) or species distribution modelling is increasingly used in decision-making regarding land use and biodiversity conservation. Model accuracy is essential, but can be affected by modelling choices, including the critical and ubiquitous question of how to define a model training domain. Theories have suggested designing a training domain based on areas accessible to a species for improved model performance (here termed as species’ mobility hypothesis).
