Xiaoan Wu

Jul 31, 2024 | nature.com | Elizabeth Kim |Xiaoan Wu |Sangyun Lee |Kevin Cunningham |Marta Perez |Peter Goldstein | +4 more

AbstractHyperpolarization-activated cyclic nucleotide-gated (HCN) channels1 are essential for pacemaking activity and neural signalling2,3. Drugs inhibiting HCN1 are promising candidates for management of neuropathic pain4 and epileptic seizures5. The general anaesthetic propofol (2,6-di-iso-propylphenol) is a known HCN1 allosteric inhibitor6 with unknown structural basis.

Apr 13, 2024 | mdpi.com | Xiaoan Wu |Kevin Cunningham |Andrew Bruening-Wright |Shilpi Pandey

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Mar 8, 2024 | preprints.org | Xiaoan Wu |Kevin Cunningham |Shilpi Pandey |Andrew Bruening-Wright

Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 7 March 2024 / Approved: 8 March 2024 / Online: 8 March 2024 (09:19:43 CET) Wu, X.; Cunningham, K.P.; Bruening-Wright, A.; Pandey, S.; Larsson, H.P. Loose Coupling between the Voltage Sensor and the Activation Gate in Mammalian HCN Channels Suggests a Gating Mechanism. Preprints 2024, 2024030499.