Xiaoliang Ba

Oct 14, 2023 | nature.com | Xiaoliang Ba |Olivier Restif |Benjamin P. Howden |Anders Larsen |Mark Holmes |Lina Maria Cavaco | +1 more

AbstractGlobal spread of multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages underscores the need for new therapeutic strategies. Here we show that many S. epidermidis isolates belonging to these lineages display cryptic susceptibility to penicillin/β-lactamase inhibitor combinations under in vitro conditions, despite carrying the methicillin resistance gene mecA. Using a mouse thigh model of S.