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Oct 23, 2024 | 
nature.com | Adrianna M Turner |Ian R. Monk |Danielle Ingle |Stephanie Portelli |Torsten Seemann |Liam Sharkey | +7 more
AbstractMultidrug-resistant bacterial pathogens like vancomycin-resistant Enterococcus faecium (VREfm) are a critical threat to human health1. Daptomycin is a last-resort antibiotic for VREfm infections with a novel mode of action2, but for which resistance has been widely reported but is unexplained. Here we show that rifaximin, an unrelated antibiotic used prophylactically to prevent hepatic encephalopathy in patients with liver disease3, causes cross-resistance to daptomycin in VREfm.
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Aug 11, 2024 | 
nature.com | Ian R. Monk |Ying-Tsun Cheng |Camilla Predella |Jack Boylan |Ahmed Moustafa |Gaurav Kumar Lohia | +5 more
AbstractStaphylococcus aureus is a pulmonary pathogen associated with substantial human morbidity and mortality. As vaccines targeting virulence determinants have failed to be protective in humans, other factors are likely involved in pathogenesis. Here we analysed transcriptomic responses of human clinical isolates of S. aureus from initial and chronic infections. We observed upregulated collagenase and proline transporter gene expression in chronic infection isolates.
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Mar 20, 2024 | 
nature.com | Yi Nong |Georgina L Pollock |Glen P. Carter |Ian R. Monk |Stanley Pang |Brian Forde | +3 more
AbstractThe past decade has seen an increase in the prevalence of sequence type (ST) 45 methicillin-resistant Staphylococcus aureus (MRSA), yet the underlying drivers for its emergence and spread remain unclear. To better understand the worldwide dissemination of ST45 S. aureus, we performed phylogenetic analyses of Australian isolates, supplemented with a global population of ST45 S. aureus genomes.
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Jan 8, 2024 | 
wwwnc.cdc.gov | Oliver Eales |Michael J. Plank |Benjamin J Cowling |Benjamin P. Howden
Ibrahim NK. Epidemiologic surveillance for controlling Covid-19 pandemic: types, challenges and implications. J Infect Public Health. 2020;13:1630–8. DOIPubMedGoogle ScholarWells CR, Townsend JP, Pandey A, Moghadas SM, Krieger G, Singer B, et al. Optimal COVID-19 quarantine and testing strategies. Nat Commun. 2021;12:356. DOIPubMedGoogle ScholarNguyen T, Adnan M, Nguyen BP, de Ligt J, Geoghegan JL, Dean R, et al.
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Oct 14, 2023 | 
nature.com | Xiaoliang Ba |Olivier Restif |Benjamin P. Howden |Anders Larsen |Mark Holmes |Lina Maria Cavaco | +1 more
AbstractGlobal spread of multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages underscores the need for new therapeutic strategies. Here we show that many S. epidermidis isolates belonging to these lineages display cryptic susceptibility to penicillin/β-lactamase inhibitor combinations under in vitro conditions, despite carrying the methicillin resistance gene mecA. Using a mouse thigh model of S.
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Aug 17, 2023 | 
microbiologyresearch.org | Susan Ballard |Norelle L. Sherry |Benjamin P. Howden |Kelly L. Wyres
1887This is a required fieldPlease enter a valid email addressApproval was a SuccessInvalid dataAn Error OccurredApproval was partially successful, following selected items could not be processed due to error Microbiology Society:http://instance.metastore.ingenta.com/content/journal/mgen/10.1099/mgen.0.00109710.1099/mgen.0.001097SEARCH_EXPAND_ITEM
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Aug 14, 2023 | 
bmcglobalpublichealth.biomedcentral.com | Angeline S. Ferdinand |Benjamin P. Howden |Glenn F Browning
Antimicrobial resistance (AMR) has been identified as a leading threat to global public health. One Health approaches that integrate sectors across human health, animal health, food production and the environment are essential to both addressing the growing threat of AMR and achieving the Sustainable Development Goals.
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Aug 10, 2023 | 
nature.com | Jessica E Stockdale |Kurnia Susvitasari |Benjamin Sobkowiak |Anne Watt |Norelle L. Sherry |Benjamin P. Howden
AbstractSerial intervals – the time between symptom onset in infector and infectee – are a fundamental quantity in infectious disease control. However, their estimation requires knowledge of individuals’ exposures, typically obtained through resource-intensive contact tracing efforts. We introduce an alternate framework using virus sequences to inform who infected whom and thereby estimate serial intervals.
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Apr 21, 2023 | 
nature.com | Lewis Mason |Sally Partridge |Jenny Draper |Indy Sandaradura |Vitali Sintchenko |Danielle Ingle | +4 more
Correction to: Nature Communications https://doi.org/10.1038/s41467-023-37672-w, published online 08 April 2023In this article the author name Elisabeth Njamkepo was incorrectly written as Elisabeth Njampeko. The original article has been corrected. Author informationAuthors and AffiliationsNIHR HPRU in Gastrointestinal Infections at University of Liverpool, Liverpool, UKLewis C. E. Mason & Kate S.
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Apr 9, 2023 | 
nature.com | Lewis Mason |Sally Partridge |Jenny Draper |Indy Sandaradura |Vitali Sintchenko |Danielle Ingle | +4 more
AbstractShigella sonnei causes shigellosis, a severe gastrointestinal illness that is sexually transmissible among men who have sex with men (MSM). Multidrug resistance in S. sonnei is common including against World Health Organisation recommended treatment options, azithromycin, and ciprofloxacin. Recently, an MSM-associated outbreak of extended-spectrum β-lactamase producing, extensively drug resistant S. sonnei was reported in the United Kingdom.
