Peter Carmeliet

Jul 10, 2024 | nature.com | Thomas Wälchli |Shigeki Takada |Hubert Rehrauer |Anuroopa Dinesh |Jeroen Bisschop |Fiona Farnhammer | +11 more

AbstractA broad range of brain pathologies critically relies on the vasculature, and cerebrovascular disease is a leading cause of death worldwide. However, the cellular and molecular architecture of the human brain vasculature remains incompletely understood1.

May 23, 2024 | nature.com | Daniel Jimenez-Blasco |Jesús Agulla |Rebeca Lapresa |Marina Garcia-Macia |Darío García-Rodríguez |Yannick Jeanson | +4 more

AbstractThe energy cost of neuronal activity is mainly sustained by glucose1,2. However, in an apparent paradox, neurons modestly metabolize glucose through glycolysis3,4,5,6, a circumstance that can be accounted for by the constant degradation of 6-phosphofructo-2-kinase–fructose-2,6-bisphosphatase-3 (PFKFB3)3,7,8, a key glycolysis-promoting enzyme.

Dec 20, 2023 | nature.com | Xiaoyi Yuan |Wei Ruan |Peter Carmeliet

AbstractHypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for adaptation of metazoans to limited oxygen availability. Recently, HIF activation and inhibition have emerged as therapeutic targets in various human diseases. Pharmacologically desirable effects of HIF activation include erythropoiesis stimulation, cellular metabolism optimization during hypoxia and adaptive responses during ischaemia and inflammation.

Mar 20, 2023 | nature.com | Jeroen Bisschop |Peter Carmeliet |Katrien De Bock |Thomas Wälchli

AbstractThe CNS critically relies on the formation and proper function of its vasculature during development, adult homeostasis and disease. Angiogenesis — the formation of new blood vessels — is highly active during brain development, enters almost complete quiescence in the healthy adult brain and is reactivated in vascular-dependent brain pathologies such as brain vascular malformations and brain tumours.