Xiaoyun Liu

Nov 28, 2024 | mdpi.com | Fang Yuan |Xiaoyun Liu |Songting Zhang |Peichao Zhu

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Jul 9, 2024 | nature.com | Zhaoming Chen |jun chen |Xiaoyun Liu |Tingting Li

AbstractWhile protein aggregation’s association with aging and age-related diseases is well-established, the specific proteins involved and whether dissolving them could alleviate aging remain unclear. Our research addresses this gap by uncovering the role of PKM2 aggregates in aging. We find that PKM2 forms aggregates in senescent cells and organs from aged mice, impairing its enzymatic activity and glycolytic flux, thereby driving cells into senescence.

Apr 24, 2024 | dialnet.unirioja.es | Xitao Wang |Lili Wang |Xiaoyun Liu |Yongping Xu

Response surface methodology based optimization for degradation of align in Laminaria japónica feedstuff via fermentation by Bacillus in Apostichopus japónicas farmingAutores: Xitao Wang, Lili Wang, Xiaoyun Liu, Yongping XuLocalización: Electronic Journal of Biotechnology, ISSN-e 0717-3458, Vol. 19, Nº. 4, 2016, págs.

Dec 14, 2023 | onlinelibrary.wiley.com | Xiaoyun Liu |Xia Wu |Wenjun Fan

1 INTRODUCTION Stomach cancer is one of the world's most frequent malignancies.1 According to the investigation, there are over one million cases of stomach cancer annually, which causes over 780 000 deaths annually.2 Nowadays, it is a huge challenge to diagnose and treat stomach cancer, and it has drawn global attention.3 Stomach mucosa or submucosa cancer is the definition of stomach cancer, irrespective of the size of the tumour or the migration of the lymph nodes.4 The Early Gastric...

Oct 28, 2023 | nature.com | Xiaoyun Liu

AbstractBidirectional signal transduction between tumor epithelial cells and tumor microenvironment (TME) is important for tumor development. Here we show that Lin28b/let-7 pathway is indispensable for modulating the expression of Wnt5a in tumor epithelium, which could be secreted and then up-regulates Lin28b in cancer-associated fibroblasts (CAFs). Moreover, we demonstrate that Lin28b in CAFs promoted growth of PDAC by inducing cytokine PCSK9’s production.