Zhaoming Chen

Jul 9, 2024 | nature.com | Zhaoming Chen |jun chen |Xiaoyun Liu |Tingting Li

AbstractWhile protein aggregation’s association with aging and age-related diseases is well-established, the specific proteins involved and whether dissolving them could alleviate aging remain unclear. Our research addresses this gap by uncovering the role of PKM2 aggregates in aging. We find that PKM2 forms aggregates in senescent cells and organs from aged mice, impairing its enzymatic activity and glycolytic flux, thereby driving cells into senescence.

Oct 31, 2023 | mdpi.com | Zhaoming Chen |Wenyuan Xu |Youyang Qu

1. IntroductionAccording to the global road safety report [], traffic crashes result in 1.2 million fatalities and over 50 million injuries annually. Traffic safety has become a significant global issue. For the traffic safety level of China, the efficiency of transportation operations has increased dramatically over the past few decades, bringing convenience but also leading to problems such as the excessive frequency and severity of crashes.